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Key takeaways Bystolic is a prescription medication used to treat high blood pressure, often prescribed when other medications are ineffective, with a retail price averaging $200 for a 30-day supply without insurance. Generic versions of Bystolic, such as nebivolol, offer cost savings, and other beta blockers can be substituted for further financial relief, though suitability varies between … BYSTOLIC is a prescription medicine that belongs to a group of medicines called "beta blockers." BYSTOLIC is used, often with other medicines, to treat adults with high blood pressure (hypertension). Nebivolol Generic Bystolic Drug Info Side Effects Dosage Medicare Scan to get these savings in the GoodRx app. Check your prescription Pricing is calculated based on your prescription details. BYSTOLIC Support and Resources Full Prescribing Information Savings Most eligible insured patients pay as little as $15 for a 30-day or 90-day prescription.* Nebivolol is used to treat high blood pressure. 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