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Prednisone is a corticosteroid used to treat a range of inflammatory and immune-related conditions. In the United States, it is a prescription medication, and buying it without a valid prescription is not legally permitted. Prednisone is a corticosteroid that has proven to be effective in treating various conditions, but is it available over-the-counter? Prednisone is a prescription drug that is not available over the counter in the United States due to its complex nature and numerous side effects. Can you get oral corticosteroids like prednisone OTC without a prescription in the U.S.? What is available and what requires a prescription. Prednisone Over The Counter: Understanding Its Role And Availability People in the medical field have been talking a lot about the issue of getting prednisone without a prescription. Prednisone is a strong corticosteroid that has been used since the 1950s to lower inflammation and suppress the immune system. 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