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NHS information about the medicine trazodone, including what it's used for, who can take it, how to take it and side effects. Taking trazodone together with anesthetic medicines (numbing medicines) that are used during surgery, dental treatments, or emergency treatments may cause an increase in CNS depressant effects. Trazodone may cause dry mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. 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Trazodone is a generic prescription drug used to treat depression in adults. Learn about cost, financial and insurance assistance, and more. Trazodone Side Effects Written by Kristianne Hannemann, PharmD on Oct 22, 2026. Common side effects Serious side effects Professional info FAQ Generic name: trazodone Brand names: Raldesy Applies to trazodone oral tablets and oral solution. Key takeaways Trazodone can cause side effects that range from mild to serious. The most common trazodone side effects are sleepiness, dry mouth, dizziness … The primary use of trazodone is the treatment of unipolar major depression with or without anxiety. [4] Data from open and double-blind trials suggest that the antidepressant efficacy of trazodone is comparable to that of amitriptyline, doxepin, and mianserin. Furthermore, trazodone has shown anxiolytic properties, low cardiotoxicity, and relatively mild side effects. 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